کتاب روشهای نوین سنتز ترکیبات آلی (MODERN METHODS OF ORGANIC SYNTHESIS) روش های نوین مورد استفاده در سنتز مواد شیمیایی آلی و مولکول های پیچیده را مورد بحث و بررسی قرار می‌دهد. این کتاب مرجع ارزشمندی برای دانشجویان، محققان و علاقه‌مندان به صنعت شیمی در زمینه سنتز پیشرفته ترکیبات آلی و استفاده از روشهای نوین سنتز است.
Contents:
1 Formation of carbon–carbon single bonds
1.1 Main-group chemistry
1.1.1 Alkylation of enolates and enamines
1.1.2 Conjugate addition reactions of enolates and enamines
1.1.3 The aldol reaction
1.1.4 Asymmetric methodology with enolates and enamines
1.1.5 Organolithium reagents
1.1.6 Organomagnesium reagents
1.1.7 Organozinc reagents
1.1.8 Allylic organometallics of boron, silicon and tin
1.2 Transition-metal chemistry
Problems
1.2.1 Organocopper reagents
1.2.2 Organochromium chemistry
1.2.3 Organocobalt chemistry
1.2.4 Organopalladium chemistry
2 Formation of carbon–carbon double bonds
2.1-Elimination reactions
2.2 Pyrolytic syn eliminations
2.3 Fragmentation reactions
2.4 Alkenes fromhydrazones
2.5 Alkenes from1,2-diols
2.6 Alkenes fromalkynes
2.7 The Wittig and related reactions
2.8 Alkenes from sulfones
2.9 Alkenes using titanium or chromium reagents
2.10 Alkene metathesis reactions
Problems
3 Pericyclic reactions
3.1 The Diels–Alder cycloaddition reaction
3.1.1 The dienophile
3.1.2 The diene
3.1.3 Regiochemistry of the Diels–Alder reaction
3.1.4 Stereochemistry of the Diels–Alder reaction
3.1.5 Intramolecular Diels–Alder reactions
3.1.6 The retro Diels–Alder reaction
3.1.7 Asymmetric Diels–Alder reactions
3.2 [2+2] Cycloaddition reactions
3.3 Cycloaddition reactions with allyl cations and allyl anions
3.4 1,3-Dipolar cycloaddition reactions
3.5 The ene reaction
3.6 [3,3]-Sigmatropic rearrangements
3.6.1 The Cope rearrangement
3.6.2 The Claisen rearrangement
3.7 [2,3]-Sigmatropic rearrangements
3.8 Electrocyclic reactions
Problems
4 Radical and carbene chemistry
4.1 Radicals
4.1.1 Radical abstraction reactions
4.1.2 Radical addition reactions
4.2 Carbenes
Problems
5 Functionalization of alkenes
5.1 Hydroboration
5.1.1 Reactions of organoboranes
5.2 Epoxidation and aziridination
5.2.1 Epoxidation
5.2.2 Asymmetric epoxidation
5.2.3 Aziridination
5.3 Dihydroxylation
5.3.1 Dihydroxylation with osmium tetroxide
5.3.2 Other methods of dihydroxylation
5.3.3 Amino-hydroxylation
5.4 Oxidative cleavage
5.5 Palladium-catalysed oxidation of alkenes
Problems
6 Oxidation
6.1 Oxidation of hydrocarbons
6.1.1 Alkanes
6.1.2 Aromatic hydrocarbons
6.1.3 Alkenes
6.2 Oxidation of alcohols
6.2.1 Chromium reagents
6.2.2 Oxidation via alkoxysulfonium salts
6.2.3 Manganese reagents
6.2.4 Other metal-based oxidants
6.2.5 Other non-metal-based oxidants
6.2.6 Oxidation to carboxylic acids or esters
6.3 Oxidation of ketones
6.3.1 Unsaturated ketones
6.3.2 Hydroxy-ketones
6.3.3 Baeyer–Villiger oxidation of ketones
Problems
7 Reduction
7.1 Catalytic hydrogenation
7.2 Reduction by dissolving metals
7.3 Reduction by hydride-transfer reagents
7.3.3 Derivatives of lithium aluminium hydride and sodium borohydride
7.3.4 Mixed lithium aluminium hydride–aluminium chloride reagents
7.3.5 Diisobutylaluminium hydride (DIBAL-H)
7.3.6 Sodium cyanoborohydride and sodium triacetoxyborohydride
7.3.7 Borane and derivatives
7.4 Other methods of reduction
7.4.1 Enzyme catalysed
7.4.2 Wolff–Kishner reduction
7.4.3 Reductions with diimide
7.4.4 Reductions with trialkylsilanes
Problems
Answers to problems
Index
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